Delivering intelligible audio is almost always a challenge at a unique venue. How many delegates will attend and where will they be? The sound system needs to be designed to reach everyone.
Many historic buildings have wonderful grand foyers to hold an event. Often this means that there are very high ceilings and the walls, floors and ceilings are made of hard materials (think granite and marble). This means that sound waves are not absorbed by the building envelope and instead they bounce off the walls as reverberations. Too much reverb and the sound becomes muddy and rendered unintelligible. In this situation many small speakers should be placed as close to the audience as possible so they move the air as little as possible. Large speaker stacks at the side of the stage will send strong sound waves that bounce back and forth around the room. Many small speakers producing lower volumes will help control the sound waves.